![]() Supra-therapeutic acetaminophen overdose over prolonged period over time or staggered, intended or unintended.Single recent acetaminophen overdose with purposeful intent.It is useful to think of the clinical presentation as one of the 3 scenarios to help guide management: Margaret Thompson answer questions such as: how is massive acetaminophen overdose a totally different toxidrome compared to non-massive overdose? Which patients are the ones that we are most likely to miss and have poor outcomes? What are the common ways in which we misinterpret the Rumack-Matthew nomogram? What are indications for fomepizole and dialysis after acetaminophen poisoning? Is hyperphosphatemia the best predictor of need for liver transplant in acetaminophen poisoning? and many more…ģ clinical presentation scenarios of acetaminophen poisoning We’re hoping that by the end of this episode you will recognize all the places where it is easy to trip up in managing these patients and provide stellar care for your next acetaminophen overdose patient. But there are many points along the way of taking care of these patients where pitfalls can rear their ugly heads leading to less than ideal outcomes. ![]() ![]() Some acetaminophen overdoses are easy to diagnose and relatively straightforward to manage in the ED. With that much acetaminophen being ingested it’s no surprise that about 10,000 people in Canada every year overdose on it. A whopping 1 billion doses of acetaminophen (or paracetamol, as it’s called in some countries) are taken safely each year.
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